Human Participant

The Uzbek Scientific Journal of Internal Diseases is committed to ensuring the ethical conduct of research involving human participants, their data, or biological material. Authors are responsible for ensuring that their research adheres to the highest ethical standards, as outlined by national and international guidelines, including the Declaration of Helsinki. This policy provides the framework for obtaining ethics approval, handling retrospective studies, and reporting research involving human participants in compliance with ethical and legal standards.

Ethics Approval

When reporting research involving human participants, their data, or biological material, authors must include a statement confirming that the study was approved by an appropriate ethics committee. The ethics committee should be institutional, national, or independent, and the name of the committee must be provided, along with the approval number if available.

  • Compliance with Ethical Standards: The study must be conducted in accordance with the ethical standards set forth in the 1964 Declaration of Helsinki and its later amendments, or comparable ethical standards.
  • Explanation for Non-Compliance: If there are aspects of the study that do not fully comply with the Declaration of Helsinki, authors must provide a detailed explanation and show that an independent ethics committee or institutional review board explicitly approved those aspects of the research.
  • Exemptions: If the study was granted an exemption from ethics approval, authors should explain the reasons for the exemption, along with the details of the committee granting the exemption.

Retrospective Ethics Approval

If a study was not approved by an ethics committee before it began, retrospective ethics approval usually cannot be obtained. In such cases, the manuscript may not be considered for peer review. Whether or not to proceed with peer review in these cases will be at the discretion of the Editor-in-Chief.

  • Retrospective Studies: Authors should note that while retrospective studies are conducted using existing data or biological material, ethics approval may still be required, depending on local and national laws and ethical guidelines. Authors must check with their institutions to ensure compliance with these requirements.

Ethics Approval for Case Studies

  • Case Reports: Case reports must be approved by an ethics committee. Authors are required to confirm that the appropriate ethics approval has been obtained from their institution and provide details of the approval.
  • Informed Consent: Authors must also ensure that informed consent is obtained from the individual patient (or their parent/legal guardian if the participant is a minor or incapacitated). If there are any concerns regarding the privacy or identity of individuals, additional precautions should be taken.

Cell Lines

If human cell lines are used in the research, authors must provide detailed information about the cell lines, including the source of the cells, the cell line’s identity (including batch number), and any authentication methods used to verify the cell line. This is essential to ensure the validity of the research and to avoid misidentification or contamination of cell lines.

  • Declaration Requirements: Authors must include the name of the company or source that provided the cells, the cell type, and the batch number. It is recommended that authors verify cell line identity using resources such as the NCBI database to prevent misidentification or contamination.
  • Ethical Approval: If the study involves human cell lines, authors must confirm that the research was approved by an ethics committee and that informed consent was obtained from the donor or the next of kin if applicable.

Research Resource Identifiers (RRID)

To enhance the reproducibility and transparency of biological research, the Uzbek Scientific Journal of Internal Diseases encourages authors to use Research Resource Identifiers (RRID) for key biological resources such as antibodies, cell lines, model organisms, and tools. RRIDs are persistent, unique identifiers that allow readers to trace the origins of resources and verify their authenticity.

  • Examples of RRID Usage:
    • Organism: Filip1tm1a(KOMP)Wtsi RRID: MMRRC_055641-UCD
    • Cell Line: RST307 cell line RRID: CVCL_C321
    • Antibody: Luciferase antibody DSHB Cat# LUC-3, RRID: AB_2722109
    • Software: ImageJ Version 1.2.4 RRID: SCR_003070

Authors should obtain RRIDs from the Resource Identification Portal and include them in the manuscript.

Clinical Trial Registration

Authors must ensure that any prospective clinical trials (Phase II to IV) are registered in a publicly available registry, such as www.clinicaltrials.gov, or any of the primary registries participating in the WHO International Clinical Trials Registry Platform.

  • Registration Requirements:
    • The Trial Registration Number (TRN) and the date of registration must be included in the last line of the manuscript abstract.
    • Retrospective Registration: If the clinical trial was not registered prospectively, authors are encouraged to register it retrospectively and include the registration details in the manuscript.

Purely observational studies do not require clinical trial registration.

Standards of Reporting

The Uzbek Scientific Journal of Internal Diseases advocates for complete and transparent reporting of biomedical and biological research. Authors are encouraged to follow recognized reporting standards based on the EQUATOR Network.

  • Recommended Reporting Guidelines:
    • CONSORT for randomized trials
    • STROBE for observational studies
    • PRISMA for systematic reviews and meta-analyses
    • CARE for case reports
    • ARRIVE for animal pre-clinical studies
    • SQUIRE for quality improvement studies
    • CHEERS for economic evaluations

Authors should consult the journal’s Instructions for Authors for specific reporting requirements.

Summary of Requirements

All relevant ethical considerations must be summarized in a "Declarations" section before the reference list in the manuscript. Other required declarations include:

  • Funding: Disclose funding sources for the research.
  • Conflicts of Interest/Competing Interests: Declare any potential conflicts of interest.
  • Ethics Approval: Confirm that the study has received ethics approval from the appropriate committee.
  • Consent: Provide statements regarding consent to participate and consent to publish.
  • Data and/or Code Availability: Indicate whether research data or code is available for public access.
  • Authors’ Contribution Statements: Clarify the contributions of each author to the study.

If any sections do not apply to the manuscript, authors should include the heading and note "Not applicable."

Failure to Meet Ethical Guidelines

The Uzbek Scientific Journal of Internal Diseases reserves the right to reject manuscripts that do not meet the ethical standards outlined in this policy. In cases where ethical violations are discovered post-publication, the journal may take corrective actions, including issuing corrections, retractions, or expressions of concern, depending on the severity of the violation.


ISSN 0000-0000 (Online)